NPFFR2 and NPY

Data Source:
HPRD (in vivo)

		NPFFR2	NPY
Description		neuropeptide FF receptor 2	neuropeptide Y
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Actin Cytoskeleton	Extracellular Region Extracellular Space Golgi Apparatus Synapse Neuronal Dense Core Vesicle
	Molecular Function	G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Opioid Receptor Binding Peptide Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Detection Of Abiotic Stimulus Regulation Of MAPK Cascade Regulation Of Adenylate Cyclase Activity Regulation Of CAMP-dependent Protein Kinase Activity	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Adult Feeding Behavior Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Intestinal Epithelial Cell Differentiation
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs			Phentermine 2-aminoisobutyric acid L-tyrosinamide
Diseases
GWAS			Adult body size ( 32376654) Aggressive periodontitis (sex interaction) ( 25256105) Body size at age 10 ( 32376654) Chronotype ( 30696823) Morning person ( 30696823) Periodontitis ( 23459936) Vitamin D levels ( 25208829)
Interacting Genes		6 interacting genes: FKBP7 HCRT NPFF NPY TMEM218 TRARG1	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		10886	4852
HPRD ID		16244	01214
Ensembl ID		ENSG00000056291	ENSG00000122585
Uniprot IDs		A0PJM9 Q9Y5X5	A4D158 P01303
PDB IDs			1QFA 1RON
Enriched GO Terms of Interacting Partners?
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