FGL2 and ATP2A2

Data Source:
HPRD (in vitro)

		FGL2	ATP2A2
Description		fibrinogen like 2	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Fibrinogen Complex Extracellular Space Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Apical Ectoplasmic Specialization Ribbon Synapse Plasma Membrane Bounded Cell Projection
	Molecular Function	Signaling Receptor Binding Extracellular Matrix Structural Constituent Peptidase Activity	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism ATPase Activity Enzyme Binding Lutropin-choriogonadotropic Hormone Receptor Binding Ion Channel Binding S100 Protein Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
	Biological Process	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Macrophage Antigen Processing And Presentation Proteolysis Neutrophil Degranulation Negative Regulation Of Memory T Cell Differentiation Negative Regulation Of Defense Response To Virus	Regulation Of The Force Of Heart Contraction Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Organelle Organization Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Lipopolysaccharide T-tubule Organization Ion Transmembrane Transport Cellular Response To Oxidative Stress Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Receptor Binding Proton Transmembrane Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Neutrophil degranulation	Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs			Desflurane Istaroxime
Diseases			Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		Crohn's disease ( 30500874)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 28991256 25056061 29483656 30285260) Waist circumference ( 28552196)
Interacting Genes			13 interacting genes: BCL2 CAMK2A CCR4 CHRM5 F2RL1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 TRIM14
Entrez ID		10875	488
HPRD ID		16098	00161
Ensembl ID		ENSG00000127951	ENSG00000174437
Uniprot IDs		A4D1B8 Q14314	A0A0S2Z3L2 P16615
PDB IDs			5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2
Enriched GO Terms of Interacting Partners?
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