ATP2A2

Description		ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Vesicle Membrane Membrane Sarcoplasmic Reticulum Platelet Dense Tubular Network Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein-containing Complex Sarcoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm Apical Ectoplasmic Specialization Ribbon Synapse Plasma Membrane Bounded Cell Projection
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Calcium Ion Binding Protein Binding ATP Binding Proton-exporting ATPase Activity, Phosphorylative Mechanism ATPase Activity Enzyme Binding Lutropin-choriogonadotropic Hormone Receptor Binding Ion Channel Binding S100 Protein Binding Calcium-transporting ATPase Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential
	Biological Process	Regulation Of The Force Of Heart Contraction Skeletal Muscle Contraction Cellular Calcium Ion Homeostasis ER-nucleus Signaling Pathway Organelle Organization Cell Adhesion Epidermis Development Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Lipopolysaccharide T-tubule Organization Ion Transmembrane Transport Cellular Response To Oxidative Stress Cellular Response To Heat Response To Endoplasmic Reticulum Stress Negative Regulation Of Heart Contraction Relaxation Of Cardiac Muscle Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Regulation Of Cardiac Muscle Cell Membrane Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Negative Regulation Of Receptor Binding Proton Transmembrane Transport Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Cardiac Conduction Calcium Ion Import Into Sarcoplasmic Reticulum
Pathways		Pre-NOTCH Processing in Golgi Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		Desflurane Istaroxime
Diseases		Acrokeratosis verruciformis Darier disease; Dyskeratosis follicularis
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glucose homeostasis traits ( 25524916) Protein quantitative trait loci ( 18464913) QT interval ( 24952745 29874175) Schizophrenia ( 28991256 25056061 29483656 30285260) Waist circumference ( 28552196)
Novel Interacting Genes		3 novel interacting genes: FGL2 SMCO4 UNG
Interacting Genes		13 interacting genes: BCL2 CAMK2A CCR4 CHRM5 F2RL1 HGS IRS1 IRS2 MDM2 PLN S100A1 SPP1 TRIM14
Entrez ID		488
HPRD ID		00161
Ensembl ID		ENSG00000174437
Uniprot IDs		A0A0S2Z3L2 P16615
PDB IDs		5ZTF 6JJU 6LLE 6LLY 6LN5 6LN6 6LN7 6LN8 6LN9 7BT2
Enriched GO Terms of Interacting Partners?
Tagcloud ?