CGB3 and LHCGR

Data Source:
HPRD (in vivo)

		CGB3	LHCGR
Description		chorionic gonadotropin subunit beta 3	luteinizing hormone/choriogonadotropin receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Hormone Activity Protein Binding	Luteinizing Hormone Receptor Activity G Protein-coupled Peptide Receptor Activity Choriogonadotropin Hormone Receptor Activity Choriogonadotropin Hormone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Gamete Generation Hormone-mediated Signaling Pathway Peptide Hormone Processing	Ovarian Follicle Development G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Male Gonad Development Hormone-mediated Signaling Pathway Ovulation Cycle Process Male Genitalia Development Positive Regulation Of Inositol Trisphosphate Biosynthetic Process Luteinizing Hormone Signaling Pathway Cognition Cellular Response To Gonadotropin Stimulus Cellular Response To Luteinizing Hormone Stimulus
Pathways		Glycoprotein hormones TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Goserelin Menotropins Lutropin alfa Cetrorelix Choriogonadotropin alfa Buserelin Chorionic Gonadotropin (Human)
Diseases			46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Premature ovarian failure Precocious puberty, including: Central precocious puberty (CEPREPU); Familial male precocious puberty (FMPP)
GWAS			Body mass index ( 28892062) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 22885925 21151128) Sex hormone-binding globulin levels ( 22829776) Triglyceride levels ( 32154731)
Interacting Genes		6 interacting genes: APP CGA FSHB LHCGR NLGN3 SMCP	11 interacting genes: ARRB2 CANX CGA CGB3 CHST9 GIPC1 GNAI2 GNAS LHB SLC9A3R1 TSHR
Entrez ID		1082	3973
HPRD ID		00343	01073
Ensembl ID		ENSG00000104827	ENSG00000138039
Uniprot IDs		A0A0F7RQP8 P0DN86	P22888
PDB IDs		1HCN 1HRP 1QFW 1XUL	1LUT 1XUL
Enriched GO Terms of Interacting Partners?
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