CPLX2 and STX3

Data Source:
HPRD (in vivo, in vitro)

		CPLX2	STX3
Description		complexin 2	syntaxin 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Dendrite SNARE Complex Terminal Bouton Perikaryon Calyx Of Held Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Synaptobrevin 2-SNAP-25-syntaxin-3-complexin Complex Postsynapse Glutamatergic Synapse	Vacuole Plasma Membrane Cell-cell Junction Synaptic Vesicle Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Dendrite Growth Cone SNARE Complex Melanosome Specific Granule Azurophil Granule Zymogen Granule Membrane Neuron Projection Presynaptic Active Zone Membrane Extracellular Exosome Schaffer Collateral - CA1 Synapse Postsynapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	SNARE Binding SNAP Receptor Activity Protein Binding Arachidonic Acid Binding
	Biological Process	Vesicle Docking Involved In Exocytosis Nervous System Development Synaptic Vesicle Exocytosis Regulation Of Exocytosis Cell Differentiation Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Synaptic Plasticity Mast Cell Degranulation Regulation Of Neurotransmitter Secretion	Intracellular Protein Transport Exocytosis Vesicle Fusion Positive Regulation Of Cell Population Proliferation Synaptic Vesicle Docking Cytokine-mediated Signaling Pathway Neuron Projection Development Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Positive Regulation Of Cell Adhesion Vesicle Docking Positive Regulation Of Chemotaxis Long-term Synaptic Potentiation Exocytic Insertion Of Neurotransmitter Receptor To Postsynaptic Membrane Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface
Pathways			Other interleukin signaling
Drugs
Diseases
GWAS		Age-related nuclear cataracts ( 24951543) Chronotype ( 30696823) Obesity-related traits ( 23251661)	High chromosomal aberration frequency (chromosome type) ( 31586183)
Interacting Genes		7 interacting genes: APP MYG1 NDRG4 PBX3 STX2 STX3 TSFM	52 interacting genes: AQP6 CD79A COQ9 CPLX2 CPLX4 CREB3L1 CYB561 DNAJC5 EBAG9 ELOVL4 ERGIC3 EVI5 FAM209A FXYD3 GPR152 GPX8 JAGN1 LMNA MANBAL MFSD14B MGST3 MMGT1 MSMO1 MTIF3 NAPB PGRMC2 REEP4 RMDN3 SCN3B SLC35C2 SNAP23 SNAP25 SNAP29 STX1A STX2 STX4 STX5 STXBP1 STXBP2 SYT1 SYT4 SYT7 TBC1D30 TMEM14B TMPPE TMX2 TRPC3 TXLNA VAMP3 VAMP7 VAMP8 ZDHHC15
Entrez ID		10814	6809
HPRD ID		09234	15985
Ensembl ID		ENSG00000145920	ENSG00000166900
Uniprot IDs		Q6PUV4	Q13277 Q53YE2
PDB IDs
Enriched GO Terms of Interacting Partners?
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