RAI1 and PEMT

Data Source:
BioGRID (affinity chromatography technology)

		RAI1	PEMT
Description		retinoic acid induced 1	phosphatidylethanolamine N-methyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Brush Border Membrane Mitochondrial Membrane Sarcolemma Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Metal Ion Binding	Phosphatidyl-N-methylethanolamine N-methyltransferase Activity Phosphatidylethanolamine N-methyltransferase Activity Phosphatidylethanolamine Binding Phosphatidyl-N-dimethylethanolamine N-methyltransferase Activity
	Biological Process	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated	Blastocyst Hatching Phosphatidylcholine Biosynthetic Process Sphingomyelin Biosynthetic Process Negative Regulation Of Cell Population Proliferation Methylation Response To Vitamin Response To Drug Response To Amino Acid Response To Ethanol S-adenosylhomocysteine Metabolic Process S-adenosylmethionine Metabolic Process Positive Regulation Of Lipoprotein Metabolic Process Positive Regulation Of Cold-induced Thermogenesis
Pathways		Circadian Clock	Synthesis of PC
Drugs
Diseases		Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome
GWAS		Body mass index ( 28892062) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) General cognitive ability ( 29844566) Hip circumference ( 25673412) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte counts ( 27863252) Offspring birth weight ( 31043758) Parkinson's disease ( 21738487) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458 30297969)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Coronary artery disease ( 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) HDL cholesterol levels ( 32203549) Mean spheric corpuscular volume ( 32888494) Obsessive-compulsive symptoms ( 26859814) Triglyceride levels ( 32203549 32154731) Triglycerides ( 30275531) Waist-hip ratio ( 28552196 25673412) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (recessive genetic model) ( 30778226) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		17 interacting genes: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TET2 TOPBP1 TTR ZNF496	4 interacting genes: AQP6 FCER1G SPP1 STOM
Entrez ID		10743	10400
HPRD ID		07406	03862
Ensembl ID		ENSG00000108557	ENSG00000133027
Uniprot IDs		Q7Z5J4	Q9UBM1
PDB IDs
Enriched GO Terms of Interacting Partners?
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