AP4B1 and BMP10

Data Source:
BioGRID (unspecified method)

		AP4B1	BMP10
Description		adaptor related protein complex 4 subunit beta 1	bone morphogenetic protein 10
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GO Annotations	Cellular Component	Trans-Golgi Network Cytosol Extrinsic Component Of Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Endosome Lumen Trans-Golgi Network Membrane	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc
	Molecular Function	Protein Binding Clathrin Binding	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding
	Biological Process	Protein Targeting Protein Localization Vesicle-mediated Transport	Kidney Development Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Signaling by BMP Molecules associated with elastic fibres
Drugs
Diseases		Cerebral palsy
GWAS		Alopecia areata ( 25608926) Breast cancer ( 23535729) Crohn's disease ( 28067908) Mean corpuscular volume ( 32888494) Obesity-related traits ( 23251661) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
Interacting Genes		6 interacting genes: AP4E1 AP4M1 BUB1 BUB1B TEPSIN ZNF576	59 interacting genes: ACVR2A ACVR2B APOA5 AQP6 ARL13B BIK BMPR2 BSCL2 BSND CCDC70 CD33 CISD2 CLDN7 COQ9 CREB3L1 DEXI EBP ERP29 FAM209A FCGR1A FCRL4 FFAR2 FKBP7 FNDC9 GGT6 GJB1 GPR152 GPX8 IL3RA JAGN1 KIR2DL3 KIR3DL1 KLRC1 LRRC25 LRRC4C MGST3 MRPS18B MS4A3 MTIF3 PLPP4 REEP4 SERINC3 SIT1 SLC10A1 SLC10A6 SLC35C2 SLC38A1 SLC4A1 SPAG4 TCTA TMEM14B TMEM31 TMEM45B TMEM86B TMPRSS2 TNFSF14 TNFSF8 TSPAN31 VSIR
Entrez ID		10717	27302
HPRD ID		06259	09788
Ensembl ID		ENSG00000134262	ENSG00000163217
Uniprot IDs		A0A024R0J5 B1ALD0 B3KSJ4 B4DTG3 Q9Y6B7	O95393
PDB IDs		2MJ7	6SF1 6SF3
Enriched GO Terms of Interacting Partners?
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