CCT8 and USP16

Data Source:
BioGRID (affinity chromatography technology)

		CCT8	USP16
Description		chaperonin containing TCP1 subunit 8	ubiquitin specific peptidase 16
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GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Extracellular Region Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cilium Secretory Granule Lumen Azurophil Granule Lumen Cell Body Intermediate Filament Cytoskeleton Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding ATP Binding ATPase Activity Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Neutrophil Degranulation Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Ub-specific processing proteases
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		3 interacting genes: ACTB APP PTEN	15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD
Entrez ID		10694	10600
HPRD ID		10816	06881
Ensembl ID		ENSG00000156261	ENSG00000156256
Uniprot IDs		P50990 Q7Z759	Q9Y5T5
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8	2I50
Enriched GO Terms of Interacting Partners?
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