GNA13 and GNA12

Data Source:
HPRD (in vivo)

		GNA13	GNA12
Description		G protein subunit alpha 13	G protein subunit alpha 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Membrane Brush Border Membrane Melanosome Extracellular Exosome	Cytoplasm Heterotrimeric G-protein Complex Plasma Membrane Focal Adhesion Lateral Plasma Membrane Brush Border Membrane
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding D5 Dopamine Receptor Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Platelet Activation Activation Of Phospholipase D Activity Positive Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Blood Coagulation Regulation Of Fibroblast Migration Platelet Activation Regulation Of TOR Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Drug
Pathways		NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Thromboxane signalling through TP receptor Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)	G alpha (12/13) signalling events Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs)
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Periventricular white matter hyperintensities ( 32517579) White matter microstructure (global fractional anisotropy) ( 24736177)	Birth weight ( 31043758 27680694) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Daytime sleep phenotypes ( 27126917) Eosinophil counts ( 32888494) Height ( 28552196 20881960 25282103 25429064 19343178 31562340 18391951 20189936) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Inflammatory bowel disease ( 28067908) Lateral ventricular volume in normal aging ( 30258056) Loneliness (linear analysis) ( 27629369) Monocyte count ( 27863252) Offspring birth weight ( 31043758) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 27863252) Subcortical volume (MOSTest) ( 32665545) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 28067908 23128233 21297633) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Weight ( 28552196) White matter integrity ( 23218918)
Interacting Genes		31 interacting genes: AIP AKAP3 ARHGEF1 ARHGEF11 ARHGEF12 CDH1 CDH2 CTNNB1 CXCR4 DRD5 EDNRB F2R GNA12 GPR17 MCF2 MTNR1A PPP5C PRKACA PRKCB PRKCD PRKCE PTK2B RDX RGS16 RIC8A S1PR2 S1PR3 S1PR4 TBXA2R TGFBR1 TSHR	30 interacting genes: ACTB AGTR1 AKAP13 APP ARAF ARHGEF11 ARHGEF12 BTK CDH1 CDH15 CDH2 DRD5 F2R GNA13 GNB1 HSP90AA1 IL3RA NAPA PPP2R1A PPP5C PRKCA PRKCB PRKCD PRKCE RASA2 S1PR4 S1PR5 TBXA2R TEC TSHR
Entrez ID		10672	2768
HPRD ID		05100	05093
Ensembl ID		ENSG00000120063	ENSG00000146535
Uniprot IDs		A0A024R8M0 Q14344	E9PC54 Q03113 Q6ZQV4
PDB IDs
Enriched GO Terms of Interacting Partners?
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