CENPE and DUX1

Data Source:
BioGRID (two hybrid)

		CENPE	DUX1
Description		centromere protein E	double homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Kinetochore Microtubule Cytosol Microtubule Microtubule Cytoskeleton Membrane Midbody Spindle Midzone Mitotic Spindle Midzone	Nucleus
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed Kinetochore Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Mitotic Cell Cycle Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organism Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins
Drugs		GSK-923295
Diseases
GWAS		Anti-chlamydia trachomatis IgG seropositivity ( 29967566) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 25877299 28604728 28604732 23666240)
Interacting Genes		12 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 DUX1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC	5 interacting genes: ACTN2 ACTN3 CENPE CSNK2B DES
Entrez ID		1062	26584
HPRD ID		00316	10609
Ensembl ID		ENSG00000138778
Uniprot IDs		Q02224	O43812 Q96PT3
PDB IDs		1T5C 5JVP
Enriched GO Terms of Interacting Partners?
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