PDLIM5 and PRKCB

Data Source:
HPRD (two hybrid, in vivo)

		PDLIM5	PRKCB
Description		PDZ and LIM domain 5	protein kinase C beta
Image
GO Annotations	Cellular Component	Stress Fiber Cytosol Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Z Disc Filamentous Actin Cell Projection Presynapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Spectrin Calyx Of Held Extracellular Exosome Presynaptic Cytosol
	Molecular Function	Actin Binding Protein Kinase C Binding Protein Binding Actinin Binding Metal Ion Binding Protein N-terminus Binding Muscle Alpha-actinin Binding Cadherin Binding Involved In Cell-cell Adhesion	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Kinase C Binding Calcium Channel Regulator Activity Protein Binding ATP Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity Histone Kinase Activity (H3-T6 Specific) Histone Binding Androgen Receptor Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Regulation Of Synapse Assembly Regulation Of Dendritic Spine Morphogenesis Cell Growth Involved In Cardiac Muscle Cell Development Muscle Structure Development Cell-cell Adhesion	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Apoptotic Process Mitotic Nuclear Envelope Disassembly Signal Transduction Regulation Of Glucose Transmembrane Transport Negative Regulation Of Glucose Transmembrane Transport Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Histone H3-T6 Phosphorylation Intracellular Signal Transduction B Cell Activation Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Myeloid Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Insulin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Carbohydrate Stimulus Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Synaptic Vesicle Exocytosis
Pathways		Neurexins and neuroligins	Disinhibition of SNARE formation Activation of NF-kappaB in B cells Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events Depolymerisation of the Nuclear Lamina WNT5A-dependent internalization of FZD4 VEGFR2 mediated cell proliferation RHO GTPases Activate NADPH Oxidases Response to elevated platelet cytosolic Ca2+ RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
Drugs			Vitamin E Tamoxifen Phosphorylcolamine Enzastaurin Ellagic acid Cholecystokinin alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Lewy body disease ( 25188341) Mean platelet volume ( 32888494 27863252) PR interval ( 32439900) Prostate cancer ( 19767753) Pulse pressure ( 30578418) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Uterine fibroids ( 31649266) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 28552196)	Blood protein levels ( 30072576) Bone mineral content ( 31790847) Cadmium levels ( 26025379) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Gut microbiota relative abundance (Dorea) ( 33208821) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Primary biliary cholangitis ( 28062665) Sleep duration ( 30531941) Ulcerative colitis ( 28067908)
Interacting Genes		14 interacting genes: ACTB ACTN1 CACNA1B CCDC136 COIL GFI1B KRT40 KRTAP10-7 NOD2 PRKCB PRKCE PRKCG TRIM39 ZYX	87 interacting genes: AFAP1 ANXA2 ANXA7 BLVRA BMPR2 BTK CARD11 CASR CD5 CHAT CHUK CISH CSF2RB CYTH2 DAB2 DVL2 EGFR EIF4E EIF6 EP300 EPB41 FBXO7 GABRB2 GABRG2 GAP43 GCNT1 GJA1 GNA12 GNA13 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A GSK3B H1-0 H1-1 H1-5 H3C1 HABP4 HSPA4 IBTK IFNAR2 IKBKB IKBKG ITGB2 ITGB7 KIT LIG1 LMNB1 LST1 MAPK6 MAPT MARCKS MBP MKI67 NCF1 NRGN NUMB PA2G4 PDLIM5 PDLIM7 PDPK1 PEBP1 PPP1CA PPP2CB PTPA PTPN11 RACK1 RASGRP3 RB1 RGS2 RIPK4 RRAD SDC2 SPTAN1 STXBP1 SYT6 TERF1 TIAM1 TINF2 TOP2A TRIM41 VTN YWHAG ZMYND8
Entrez ID		10611	5579
HPRD ID		05799	01499
Ensembl ID		ENSG00000163110	ENSG00000166501
Uniprot IDs		A0A024RDE8 B7Z481 B7Z8X5 Q96HC4	P05771
PDB IDs		2DAR 2UZC	2I0E
Enriched GO Terms of Interacting Partners?
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