TBL3 and CACNB4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TBL3	CACNB4
Description		transducin beta like 3	calcium voltage-gated channel auxiliary subunit beta 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus 90S Preribosome Small-subunit Processome	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cytoplasmic Side Of Plasma Membrane Synapse
	Molecular Function	RNA Binding Protein Binding U3 SnoRNA Binding	Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity
	Biological Process	Endonucleolytic Cleavage To Generate Mature 5'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing	Chemical Synaptic Transmission Neuromuscular Junction Development Membrane Depolarization Cardiac Conduction Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Presynaptic depolarization and calcium channel opening NCAM1 interactions
Drugs			Ergocalciferol Enflurane Ranolazine Phenytoin Topiramate Nimodipine Spironolactone Magnesium sulfate Levomenthol Miconazole Amiodarone Mibefradil Dronedarone Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Episodic ataxias Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) ( 24025145) Idiopathic dilated cardiomyopathy ( 29495422) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)
Interacting Genes		11 interacting genes: AHR APPBP2 AURKB CACNB4 CUL4B DHX30 ITSN2 NR2E3 SFN URM1 USP11	12 interacting genes: CACNA1A CBX3 CCDC102B CTBP2 EFHC2 FASLG MAP1A MED31 PTN REM1 SYT1 TBL3
Entrez ID		10607	785
HPRD ID		09327	09057
Ensembl ID		ENSG00000183751	ENSG00000182389
Uniprot IDs		Q12788	A0A1B0GTK1 A0A1B0GTP5 A0A1B0GTX8 H0Y476 O00305
PDB IDs			2D46
Enriched GO Terms of Interacting Partners?
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