USP16 and SLC34A3

Data Source:
HPRD (in vivo)

		USP16	SLC34A3
Description		ubiquitin specific peptidase 16	solute carrier family 34 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Plasma Membrane Brush Border Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Vesicle
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding	Sodium:phosphate Symporter Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division	Sodium Ion Transport Phosphate Ion Transport Cellular Phosphate Ion Homeostasis Sodium Ion Transmembrane Transport Sodium-dependent Phosphate Transport
Pathways		Ub-specific processing proteases	Type II Na+/Pi cotransporters Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH)
Drugs
Diseases			Hypophosphatemic rickets; X-Linked dominant hypophosphatemia (XLH); Autosomal dominant hypophosphatemic rickets (ADHR); Autosomal recessive hypophosphatemic rickets (ARHR); Hereditary hypophophatemic rickets with hypercalciuria (HHRH)
GWAS
Interacting Genes		15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD	4 interacting genes: CLRN1 GPX8 TMEM167B TMEM234
Entrez ID		10600	142680
HPRD ID		06881	10236
Ensembl ID		ENSG00000156256	ENSG00000198569
Uniprot IDs		Q9Y5T5	Q8N130
PDB IDs		2I50
Enriched GO Terms of Interacting Partners?
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