USP16 and CCT8

Data Source:
BioGRID (affinity chromatography technology)

		USP16	CCT8
Description		ubiquitin specific peptidase 16	chaperonin containing TCP1 subunit 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Zona Pellucida Receptor Complex Extracellular Region Nucleoplasm Cytoplasm Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cilium Secretory Granule Lumen Azurophil Granule Lumen Cell Body Intermediate Filament Cytoskeleton Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Zinc Ion Binding Histone Binding Ubiquitin Binding	Protein Binding ATP Binding ATPase Activity Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Histone H2A Deubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Elongation Positive Regulation Of Transcription By RNA Polymerase II Protein Homotetramerization Cell Division Regulation Of Cell Cycle Histone H2A K63-linked Deubiquitination Mitotic Nuclear Division	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Neutrophil Degranulation Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Ub-specific processing proteases	Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Neutrophil degranulation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		15 interacting genes: CALM1 CDK1 EXOSC10 FBXO11 H2AC18 H2AC20 H2AC4 H2AZ1 H2BC3 H4-16 PLK1 PTOV1 TTK UBC UBD	3 interacting genes: ACTB APP PTEN
Entrez ID		10600	10694
HPRD ID		06881	10816
Ensembl ID		ENSG00000156256	ENSG00000156261
Uniprot IDs		Q9Y5T5	P50990 Q7Z759
PDB IDs		2I50	6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8
Enriched GO Terms of Interacting Partners?
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