GNLY and DERL3

Data Source:
BioGRID (two hybrid)

		GNLY	DERL3
Description		granulysin	derlin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytolytic Granule Phagocytic Vesicle Lumen	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding
	Biological Process	Cellular Defense Response Antimicrobial Humoral Response Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Antimicrobial peptides	ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis
Drugs		3-(N-morpholino)propanesulfonic acid
Diseases
GWAS		Blood protein levels ( 29875488 28240269)	Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)
Interacting Genes		4 interacting genes: APP BCL2L1 DERL3 FBXO7	19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2
Entrez ID		10578	91319
HPRD ID		01788	13139
Ensembl ID		ENSG00000115523	ENSG00000099958
Uniprot IDs		B4E3H9 P22749	Q96Q80
PDB IDs		1L9L
Enriched GO Terms of Interacting Partners?
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