NPC2 and AREL1

Data Source:
BioGRID (biochemical)

		NPC2	AREL1
Description		NPC intracellular cholesterol transporter 2	apoptosis resistant E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Inflammatory Response
Pathways		Neutrophil degranulation LDL clearance	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)	General factor of neuroticism ( 30867560) Mood instability ( 29187730)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	10 interacting genes: CRKL DIABLO HTRA2 PIAS4 SEPTIN4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3
Entrez ID		10577	9870
HPRD ID		03008	13794
Ensembl ID		ENSG00000119655	ENSG00000119682
Uniprot IDs		A0A024R6C0 P61916	O15033
PDB IDs		5KWY 6W5V	6JX5
Enriched GO Terms of Interacting Partners?
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