NPC2 and EIF2B2

Data Source:
BioGRID (affinity chromatography technology)

		NPC2	EIF2B2
Description		NPC intracellular cholesterol transporter 2	eukaryotic translation initiation factor 2B subunit beta
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport Intermembrane Lipid Transfer	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway
Pathways		Neutrophil degranulation LDL clearance	Recycling of eIF2:GDP
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2	Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993) Refractive error ( 32231278)	Coronary artery disease ( 33020668) Mood instability ( 29187730) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 PCGF6 TET2
Entrez ID		10577	8892
HPRD ID		03008	05923
Ensembl ID		ENSG00000119655	ENSG00000119718
Uniprot IDs		A0A024R6C0 P61916	P49770 Q53XC2
PDB IDs		5KWY 6W5V	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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