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KAT5 and CEP126
Data Source:
HPRD
(two hybrid, in vitro)
KAT5
CEP126
Description
lysine acetyltransferase 5
centrosomal protein 126
Image
No pdb structure
GO Annotations
Cellular Component
Swr1 Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Piccolo NuA4 Histone Acetyltransferase Complex
NuA4 Histone Acetyltransferase Complex
Perinuclear Region Of Cytoplasm
Cytoplasm
Centrosome
Midbody
Ciliary Base
Molecular Function
Transcription Coregulator Activity
Transcription Coactivator Activity
Histone Acetyltransferase Activity
Protein Binding
Acetyltransferase Activity
Histone Binding
Metal Ion Binding
Peptide-lysine-N-acetyltransferase Activity
Repressing Transcription Factor Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Double-strand Break Processing
DNA Replication
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
Response To Ionizing Radiation
Positive Regulation Of Autophagy
Viral Process
Histone Acetylation
Protein Phosphopantetheinylation
Peptidyl-lysine Acetylation
Negative Regulation Of Interleukin-2 Production
Regulation Of Growth
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Protein Acetylation
Beta-catenin-TCF Complex Assembly
Mitotic Spindle Organization
Cytoplasmic Microtubule Organization
Cilium Assembly
Non-motile Cilium Assembly
Pathways
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
DNA Damage/Telomere Stress Induced Senescence
HATs acetylate histones
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Sensing of DNA Double Strand Breaks
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Resolution of D-loop Structures through Holliday Junction Intermediates
Nonhomologous End-Joining (NHEJ)
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Estrogen-dependent gene expression
Drugs
Coenzyme A
S-Acetyl-Cysteine
Diseases
GWAS
Acne (severe) (
24927181
)
Asthma (
31619474
)
Chronic kidney disease (
20383146
)
Diastolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate (
31152163
)
HDL cholesterol (
24097068
)
HDL cholesterol levels (
32203549
28334899
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Systolic blood pressure x alcohol consumption interaction (2df test) (
29912962
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Triglyceride levels (
32203549
)
Triglycerides (
30275531
)
Interacting Genes
191 interacting genes:
AGO2
ALOX12
ALX1
ANTKMT
APBB1
APLP1
APLP2
APP
AR
ARIH2
ATF3
ATM
ATXN1
BACH2
BARD1
BCL3
BLZF1
BMI1
BRCA1
C1orf131
C1orf174
CAVIN1
CBX8
CCDC106
CCDC125
CCDC136
CCNB1
CCT7
CDC42
CDK1
CDK5RAP2
CDKN2A
CEP126
CEP70
CREB1
CREBBP
CRELD1
CSTF2
DLEU1
DNAAF6
DUSP23
E2F1
E2F4
EDNRA
EFNA1
EP300
EP400
EPC1
ESR1
ESR2
ETV6
FAM135B
FAM161A
FCHO1
GADD45G
GAPDH
GEMIN7
GET4
GIGYF1
GKAP1
GMCL1
GMCL2
GOLGA2
GSTO1
GTF2E2
H2AC20
H2AC4
H2AX
H3-3B
H3-4
H3C1
H3C14
H4-16
H4C1
H4C14
HABP4
HAP1
HDAC1
HDAC7
HMBOX1
HNRNPH3
HSF2BP
ID3
IFT20
IK
IKZF3
IL9R
KCTD7
KLF4
KPNA3
KPNA4
KPNA5
KPNA6
KRT40
KRTAP10-3
KRTAP10-9
LMNA
LONRF1
LRIF1
LRP1
LZTS1
LZTS2
MAD2L1BP
MAPRE1
MCC
MCPH1
MDFI
MDM2
MEOX2
MTUS2
MYC
MYOD1
NAP1L5
NDUFA4L2
NDUFV2
NFKB1
NINL
NR3C1
ODC1
OGFOD2
PDCD5
PFKP
PHC2
PICK1
PITX2
PLA2G4A
PLEKHA4
PML
POLE2
POLR3F
PPARG
PPP1R16A
PRDM6
PROSER2
PTPN4
PTPRS
RB1
RCHY1
RELA
RFLNB
RGL2
RRM2
SAT1
SCRN2
SERTAD2
SHISA6
SNAPIN
SNRPD2
SOX5
SPATA2
SQSTM1
SRF
SRSF2
SSX2IP
STAT3
STMN3
STX11
SYCE1
SYN1
TAX1BP1
TBX5
TELO2
TFIP11
TMCC2
TNNT1
TP53
TRIB3
TRIM23
TRIM27
TRIM29
TRIM37
TUFT1
UBASH3B
UHRF1
UPRT
USP7
YJU2
YWHAG
ZBTB1
ZBTB14
ZBTB2
ZBTB8A
ZC2HC1C
ZEB1
ZNF24
ZNF417
ZNF511
ZNF513
ZNF526
ZNF692
ZSCAN4
87 interacting genes:
AIMP2
AKTIP
ARIH2
ATP6V1F
ATRX
BMI1
BRD1
C11orf58
CDKN2B
CRCT1
CSTF2
DGCR6
DISC1
DLEU1
DNM1
DUSP12
DUSP23
EIF2S2
EIF6
EPN1
FAM118B
FEZ1
FGFR3
FXR1
GEMIN7
GET4
GIT1
GOLGB1
GPRASP2
GSTO1
HMOX2
HTT
ING5
KAT5
KAT7
KIF15
KLHL20
LAMTOR5
LPL
LRRC1
LUC7L2
MAD2L1BP
MAPK9
MLH1
MRPS6
NAP1L5
NAT9
NPM3
NSF
NUDT21
ODF2L
OFD1
PBK
PDCD5
PFDN1
PIK3R3
PMF1
POLD1
POLR2M
PPP1CA
PPP1CC
PRKRA
PTPRS
RAB27A
RAN
RBM23
RETREG2
RGS2
RIF1
ROGDI
RPA2
RUVBL1
SAT1
SNRPG
SPDL1
STAU2
TFG
TNFRSF14
TNFSF11
TOMM20
TTR
TXNDC9
VIM
YAE1
YWHAZ
ZBED8
ZNF24
Entrez ID
10524
57562
HPRD ID
03245
17212
Ensembl ID
ENSG00000172977
ENSG00000110318
Uniprot IDs
A0A024R597
A0A024R5E8
Q92993
Q9P2H0
PDB IDs
2EKO
2OU2
4QQG
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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