FBLN5 and NDUFA4

Data Source:
BioGRID (affinity chromatography technology)

		FBLN5	NDUFA4
Description		fibulin 5	NDUFA4 mitochondrial complex associated
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Respiratory Chain Complex IV Integral Component Of Membrane
	Molecular Function	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity	Cytochrome-c Oxidase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Protein-containing Complex Binding
	Biological Process	Cell-matrix Adhesion Extracellular Matrix Organization Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport
Pathways		Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs			NADH
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)	Dental caries (decayed, missing and filled teeth) ( 31533690) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Heschl's gyrus morphology ( 25130324) Lung cancer ( 28604730) Mercury levels ( 26025379) Metabolite levels ( 23823483) Response to radiotherapy in nasopharyngeal carcinoma (acute oral mucositis) ( 32503578)
Interacting Genes		12 interacting genes: ATN1 GFI1B LOXL1 LPA MEOX2 NUFIP2 OTX1 PAXIP1 PRNP SOD3 TOP3B TRIP13	2 interacting genes: APP PARK7
Entrez ID		10516	4697
HPRD ID		05204	04831
Ensembl ID		ENSG00000140092	ENSG00000189043
Uniprot IDs		A0A024R6G3 Q9UBX5	A0A024R9Z0 O00483
PDB IDs			5Z62
Enriched GO Terms of Interacting Partners?
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