HOXB13 and ALX4

Data Source:
BioGRID (two hybrid)

		HOXB13	ALX4
Description		homeobox B13	ALX homeobox 4
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Transcription By RNA Polymerase II Epidermis Development Response To Wounding Response To Testosterone Regulation Of Growth Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development	Skeletal System Development Hair Follicle Development Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways
Drugs
Diseases			Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Prostate cancer ( 23104005 23535732)	Blood pressure measurement (high sodium intervention) ( 24165912) Brain morphology (MOSTest) ( 32665545) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		7 interacting genes: ALX4 ELK1 HOXD4 IRF4 MEIS1 POU2F1 ZNF490	14 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 IQUB LEF1 PARVG SOX10 SOX2
Entrez ID		10481	60529
HPRD ID		05210	05661
Ensembl ID		ENSG00000159184	ENSG00000052850
Uniprot IDs		Q4KR72 Q92826	Q9H161
PDB IDs		2CRA 5EDN 5EEA 5EF6 5EG0 5EGO 5NO6	2M0C
Enriched GO Terms of Interacting Partners?
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