VAV3 and RINT1

Data Source:
BioGRID (two hybrid)

		VAV3	RINT1
Description		vav guanine nucleotide exchange factor 3	RAD50 interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Cytosol	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Dsl1/NZR Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Angiogenesis Vesicle Fusion Cellular Response To DNA Damage Stimulus G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Regulation Of Cell Size Lamellipodium Assembly Platelet Activation Neutrophil Chemotaxis Positive Regulation Of B Cell Proliferation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Response To Drug Positive Regulation Of Apoptotic Process Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Cell Cycle Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Pathways		GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin) ( 23648065) Asthma and hay fever ( 24388013) Autoimmune thyroid disease ( 32581359) Bipolar disorder ( 31043756) Differentiated thyroid cancer ( 28703219) Eosinophil percentage of white cells ( 32888494) Hashimoto thyroiditis versus Graves' disease ( 25429627) Hip circumference adjusted for BMI ( 28552196) Hypothyroidism ( 30367059 27182965 22493691) IgA nephropathy ( 25305756) Medication use (thyroid preparations) ( 31015401) Night sleep phenotypes ( 27126917) Papillary thyroid cancer ( 28703219) Plasma thyroid-stimulating hormone levels ( 24722205) Refractive error ( 32231278) Response to antiepileptic mood-stabilizing treatment in bipolar disorder ( 32627186) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		25 interacting genes: AR CBLB EGFR ERBB2 ERBB3 ERBB4 ESR1 GAB1 GRB2 IGF1R INSR KIT LCP2 MET PIK3R1 PLCG1 RAC1 RHOA RHOG RINT1 ROS1 SH3BP2 SHC1 ZRANB1 ZYX	102 interacting genes: ANKRD11 ARHGAP45 ARNT2 BFSP2 BLOC1S6 BNIP3L C19orf25 C19orf44 C1orf109 C1orf35 CCDC120 CCDC121 CCDC146 CCDC187 CCDC57 CCDC88B CCHCR1 CDR2L CEP57L1 CSPP1 CWF19L2 DCTN2 DCX DPF2 EPC1 ESRRG EXOC8 FAM107A FAM110A FAM124B FAM161A FAM161B FAM81B FAM90A1 FANCG FCHSD2 GAS8 GFI1B GRAP2 HDAC4 HGS INPP5J JMY KIAA1217 KRT1 LMO2 LSP1P3 LYSMD1 MBD3 MCM7 MISP MYOZ3 NAB2 NFIL3 PCM1 PIK3R2 PIMREG PRPF18 PRPF31 PSTPIP1 RAD50 RAMAC RB1 RBL1 RBL2 RBM41 RIBC1 RNF39 RNF6 RSRC2 RTP5 SCNM1 SFR1 SGF29 SH2D4A SMARCB1 SMARCE1 SNW1 SPTBN1 STRN SUOX TACO1 TEX9 TRIM69 TSEN54 TSHZ2 TSHZ3 TXLNA USHBP1 UTP14C VAV3 VPS37C XPNPEP1 ZBTB16 ZC2HC1C ZNF648 ZNF655 ZNF688 ZNF697 ZNF835 ZSCAN5B ZW10
Entrez ID		10451	60561
HPRD ID		05706	15250
Ensembl ID		ENSG00000134215	ENSG00000135249
Uniprot IDs		Q9UKW4	Q6NUQ1
PDB IDs		2D86
Enriched GO Terms of Interacting Partners?
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