CDKN2C and MTA3

Data Source:
BioGRID (two hybrid)

		CDKN2C	MTA3
Description		cyclin dependent kinase inhibitor 2C	metastasis associated 1 family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Cytoplasm NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Oligodendrocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Atrial fibrillation ( 29290336) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 31562340) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)	Breastfeeding duration ( 25475840)
Interacting Genes		58 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 CRX CTDSP1 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 KRT31 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PBX4 PDGFRA PLEKHG4 POU6F2 PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 SORBS3 ST14 STK11 TCF12 TCF4 TLE1 TP53 UNC119	21 interacting genes: AKT1 ARNT ATM AURKA BAG4 BCAR3 BCL6 CDKN2C ERCC6 FGFR2 FGFR4 FOXK2 FZR1 GRB2 IGF1R KDM1A NACC2 NOTCH2 PARP1 TGFB1 TSG101
Entrez ID		1031	57504
HPRD ID		04534	12359
Ensembl ID		ENSG00000123080	ENSG00000057935
Uniprot IDs		P42773 Q6ICV4	F6RRE2 Q9BTC8
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?
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