SIGMAR1 and DCAF12

Data Source:
BioGRID (biochemical)

		SIGMAR1	DCAF12
Description		sigma non-opioid intracellular receptor 1	DDB1 and CUL4 associated factor 12
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GO Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Postsynaptic Density Membrane Integral Component Of Membrane Growth Cone Cytoplasmic Vesicle Postsynaptic Density Membrane	Cytoplasm Centrosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Opioid Receptor Activity Protein Binding	Protein Binding
	Biological Process	Lipid Transport Nervous System Development Cell Death In Response To Hydrogen Peroxide Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization	Protein Ubiquitination
Pathways		Potential therapeutics for SARS
Drugs		Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Noscapine Captodiame Pentoxyverine
Diseases
GWAS			BRCA1/2-negative high-risk breast cancer ( 30323354) Estimated glomerular filtration rate ( 31015462 30604766) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Platelet distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ANK2 ITPR3 PDZD11	2 interacting genes: BMPR1B TGFBR1
Entrez ID		10280	25853
HPRD ID		03580	10031
Ensembl ID		ENSG00000147955	ENSG00000198876
Uniprot IDs		A2A3U5 B4DR71 Q99720	Q5T6F0
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1	3I7P
Enriched GO Terms of Interacting Partners?
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