EFS and BDKRB2

Data Source:
BioGRID (two hybrid)

		EFS	BDKRB2
Description		embryonal Fyn-associated substrate	bradykinin receptor B2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Focal Adhesion	Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding SH3 Domain Binding Protein Domain Specific Binding	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Intracellular Signal Transduction Actin Filament Reorganization	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases
GWAS			Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		35 interacting genes: ABI2 AGXT APP BCAR1 BDKRB2 BLK CCDC187 CRK FYN GLMN GPANK1 LHX8 LYST MYOZ3 NCK1 NCK2 NLGN3 NPAS2 NUP155 OSTF1 PIN1 PTK2 PTK2B PTPN12 SH2D3C SH3RF2 SORBS2 SORBS3 SRC TRAPPC6A TSSK1B UBASH3B UBC YES1 ZNF417	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		10278	624
HPRD ID		09932	00213
Ensembl ID		ENSG00000100842	ENSG00000168398
Uniprot IDs		O43281	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?
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