TRAP1 and ESX1

Data Source:
BioGRID (two hybrid)

		TRAP1	ESX1
Description		TNF receptor associated protein 1	ESX homeobox 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane	Chromatin Nucleus Cytoplasm Nuclear Speck
	Molecular Function	RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Unfolded Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Folding Translational Attenuation Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle
Pathways		Respiratory electron transport
Drugs
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		16 interacting genes: APP ESX1 EXT1 EXT2 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	2 interacting genes: EXOC2 TRAP1
Entrez ID		10131	80712
HPRD ID		05868	06503
Ensembl ID		ENSG00000126602	ENSG00000123576
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	Q8N693
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05
Enriched GO Terms of Interacting Partners?
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