ACTR2 and FCGR2A

Data Source:
BioGRID (affinity chromatography technology)

		ACTR2	FCGR2A
Description		actin related protein 2	Fc fragment of IgG receptor IIa
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Actin Cap Azurophil Granule Lumen Site Of Double-strand Break Podosome Core Extracellular Exosome Ficolin-1-rich Granule Lumen	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Actin Filament Binding	Transmembrane Signaling Receptor Activity Protein Binding IgG Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Associative Learning Asymmetric Cell Division Positive Regulation Of Lamellipodium Assembly Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Response To Immobilization Stress Cellular Response To Trichostatin A Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Regulation Of Immune Response
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one	Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Calcific aortic valve stenosis ( 32141789) Coronary artery disease ( 29212778 33020668) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)
Interacting Genes		14 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 ELF5 ERCC6 HCLS1 IQGAP2 SHARPIN WASF1 WASF2 WASL	26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2
Entrez ID		10097	2212
HPRD ID		05023	00906
Ensembl ID		ENSG00000138071	ENSG00000143226
Uniprot IDs		P61160	P12318
PDB IDs		6UHC 6YW6 6YW7	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?
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