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ABCF2 and HADHA
Data Source:
BioGRID
(two hybrid)
ABCF2
HADHA
Description
ATP binding cassette subfamily F member 2
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Image
No pdb structure
GO Annotations
Cellular Component
Membrane
Mitochondrion
Mitochondrial Inner Membrane
Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex
Mitochondrial Nucleoid
Molecular Function
ATP Binding
ATPase Activity
3-hydroxyacyl-CoA Dehydrogenase Activity
Acetyl-CoA C-acetyltransferase Activity
Enoyl-CoA Hydratase Activity
Protein Binding
Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity
Biological Process
Fatty Acid Beta-oxidation
Cardiolipin Acyl-chain Remodeling
Pathways
Acyl chain remodeling of CL
Beta oxidation of myristoyl-CoA to lauroyl-CoA
mitochondrial fatty acid beta-oxidation of unsaturated fatty acids
Beta oxidation of palmitoyl-CoA to myristoyl-CoA
Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
Beta oxidation of octanoyl-CoA to hexanoyl-CoA
Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs
NADH
Diseases
Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP)
Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS
Eyebrow thickness (
26926045
)
Femoral neck bone mineral density (
22504420
)
Height (
31562340
)
IgG glycosylation (
23382691
)
IgG N-glycosylation phenotypes (multivariate analysis) (
32128391
)
Pre-treatment viral load in HIV-1 infection (
31219150
)
Interacting Genes
4 interacting genes:
ANKRD28
HADHA
PTEN
UPF2
8 interacting genes:
ABCF2
ATXN2L
CD74
HSD17B10
NR4A1
PIN1
PTEN
YWHAQ
Entrez ID
10061
3030
HPRD ID
12403
02934
Ensembl ID
ENSG00000033050
ENSG00000084754
Uniprot IDs
A0A090N7X1
Q9UG63
E9KL44
P40939
PDB IDs
5ZQZ
5ZRV
6DV2
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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