HCN4 and HCN2

Data Source:
HPRD (in vitro, in vivo)

		HCN4	HCN2
Description		hyperpolarization activated cyclic nucleotide gated potassium channel 4	hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
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GO Annotations	Cellular Component	Plasma Membrane Intrinsic Component Of Plasma Membrane Perinuclear Region Of Cytoplasm HCN Channel Complex	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex HCN Channel Complex
	Molecular Function	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity CAMP Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In SA Node Cell Action Potential Depolarization	Intracellular CAMP-activated Cation Channel Activity Voltage-gated Sodium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding CAMP Binding Identical Protein Binding
	Biological Process	Regulation Of Heart Rate Regulation Of Membrane Depolarization Cation Transport Muscle Contraction Blood Circulation Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Regulation Of Cardiac Muscle Contraction Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Sodium Ion Import Across Plasma Membrane Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Potassium Ion Import Across Plasma Membrane	Cell-cell Signaling Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Membrane Potential Cellular Response To CAMP Cellular Response To CGMP Potassium Ion Transmembrane Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Sodium Ion Import Across Plasma Membrane Potassium Ion Import Across Plasma Membrane
Pathways		HCN channels	HCN channels
Drugs			Cyclic GMP Cyclic adenosine monophosphate Ivabradine
Diseases		Sick sinus syndrome (SSS); Sinus node dysfunction Brugada syndrome (BRS)
GWAS		Atrial fibrillation ( 28416818 30061737 29892015 22544366) Brain morphology (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Heart rate variability traits (pvRSA/HF) ( 28613276) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Heel bone mineral density ( 30598549) Nickel levels ( 26025379) PR interval ( 32439900) Resting heart rate ( 29769521 27798624) Triglyceride levels ( 32203549) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		1 interacting genes: HCN2	2 interacting genes: HCN1 HCN4
Entrez ID		10021	610
HPRD ID		09240	07213
Ensembl ID		ENSG00000138622	ENSG00000099822
Uniprot IDs		Q9Y3Q4	Q9UL51
PDB IDs		2MNG 3OTF 3U11 4HBN 4KL1 4NVP 6GYN 6GYO	2MPF 3U10
Enriched GO Terms of Interacting Partners?
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