MED6 and SUZ12

Data Source:
BioGRID (pull down)

		MED6	SUZ12
Description		mediator complex subunit 6	SUZ12 polycomb repressive complex 2 subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Nucleolus Nuclear Body ESC/E(Z) Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding	RNA Polymerase II Transcription Corepressor Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific)
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II	Spinal Cord Development Response To Retinoic Acid Negative Regulation Of Chemokine Production Negative Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Trimethylation
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS			High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		15 interacting genes: BCL6 CTDP1 ESR1 ESR2 MED25 MED8 MED9 PARP1 RARA SMAD1 SMAD2 SMARCA4 SREBF1 SUZ12 TARDBP	17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77
Entrez ID		10001	23512
HPRD ID		04284	06949
Ensembl ID		ENSG00000133997	ENSG00000178691
Uniprot IDs		A0A087WYL7 O75586	J3QQW9 Q15022
PDB IDs			4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24 6NQ3
Enriched GO Terms of Interacting Partners?
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