PARP3 and BAP1

Data Source:
HPRD (in vivo)

		PARP3	BAP1
Description		poly(ADP-ribose) polymerase family member 3	BRCA1 associated protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Centriole Nuclear Body Site Of Double-strand Break Intercellular Bridge	Nucleus Nucleoplasm Cytoplasm Cytosol PR-DUB Complex
	Molecular Function	Catalytic Activity NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Chromatin Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Protein ADP-ribosylation DNA ADP-ribosylation Negative Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Telomerase RNA Reverse Transcriptase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Population Proliferation Response To Inorganic Substance Protein Deubiquitination Protein Phosphopantetheinylation Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Negative Regulation Of Transcription, DNA-templated Regulation Of Inflammatory Response Regulation Of Cell Cycle Macrophage Homeostasis Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Drugs		2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one -ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)
Interacting Genes		4 interacting genes: APP H1-1 MEOX2 PARP1	27 interacting genes: BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 IGF1R ITPR3 KLF5 LINC00598 MAP3K1 NBN PTPRJ RB1CC1 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1
Entrez ID		10039	8314
HPRD ID		06370	04366
Ensembl ID		ENSG00000041880	ENSG00000163930
Uniprot IDs		A0A024R318 Q9Y6F1	A0A024R305 F8W6N3 Q92560
PDB IDs		2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?
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