AMBRA1 - HiPPIP

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ALX4	ALX homeobox 4
BECN1	beclin 1	Macroautophagy Ub-specific processing proteases Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex	Estradiol Estradiol acetate Estradiol benzoate Estradiol cypionate Estradiol dienanthate Estradiol valerate
CHUK	component of inhibitor of nuclear factor kappa B kinase complex	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Aminosalicylic acid Mesalazine Sulfasalazine Acetylcysteine
CREM	cAMP responsive element modulator
CUL4B	cullin 4B	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
GABARAP	GABA type A receptor-associated protein	Macroautophagy TBC/RABGAPs
GABARAPL1	GABA type A receptor associated protein like 1	Macroautophagy
GABARAPL2	GABA type A receptor associated protein like 2	Macroautophagy TBC/RABGAPs
HSD17B12	hydroxysteroid 17-beta dehydrogenase 12	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
KBTBD4	kelch repeat and BTB domain containing 4
MAP1LC3A	microtubule associated protein 1 light chain 3 alpha	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
MAP1LC3B	microtubule associated protein 1 light chain 3 beta	Macroautophagy PINK1-PRKN Mediated Mitophagy TBC/RABGAPs Receptor Mediated Mitophagy Pexophagy Translation of Replicase and Assembly of the Replication Transcription Complex Translation of Replicase and Assembly of the Replication Transcription Complex
MAP1LC3C	microtubule associated protein 1 light chain 3 gamma	Macroautophagy
MTCH2	mitochondrial carrier 2
MTOR	mechanistic target of rapamycin kinase	PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1	Pimecrolimus Sirolimus Everolimus Rimiducid SF1126 XL765 Ridaforolimus Temsirolimus Fostamatinib
PEX11A	peroxisomal biogenesis factor 11 alpha	PPARA activates gene expression
RNF2	ring finger protein 2	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
SLC35C1	solute carrier family 35 member C1	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) GDP-fucose biosynthesis Transport of nucleotide sugars
SNCA	synuclein alpha	Amyloid fiber formation	Resveratrol Copper
UBE2D3	ubiquitin conjugating enzyme E2 D3	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation

Search Results for: AMBRA1