AMBRA1 and HSD17B12

		AMBRA1	HSD17B12
Description		autophagy and beclin 1 regulator 1	hydroxysteroid 17-beta dehydrogenase 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Fatty Acid Elongase Complex Integral Component Of Membrane Extracellular Matrix
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	Fibronectin Binding Protein Binding Collagen Binding Heparin Binding Oxidoreductase Activity Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity 17-beta-hydroxysteroid Dehydrogenase (NAD+) Activity Long-chain-fatty-acyl-CoA Reductase Activity 17-beta-hydroxysteroid Dehydrogenase (NADP+) Activity 3-oxo-arachidoyl-CoA Reductase Activity 3-oxo-behenoyl-CoA Reductase Activity 3-oxo-lignoceroyl-CoA Reductase Activity 3-oxo-cerotoyl-CoA Reductase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Fatty Acid Biosynthetic Process Estrogen Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Long-chain Fatty-acyl-CoA Biosynthetic Process
Pathways		Macroautophagy	Androgen biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Birth length ( 25281659) Body mass index ( 26961502 25673413 29273807) Chronotype ( 30696823) Coronary artery disease ( 29212778 33020668) Essential hypertension (time to event) ( 32589924) FEV1 ( 30804560) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Lung function (forced vital capacity) ( 24929828) Lung function (FVC) ( 30804560) Morning person ( 30696823) Neuroblastoma ( 22941191) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Sleep start time ( 33075057) Sporadic neuroblastoma ( 28545128) Type 2 diabetes ( 28566273 30297969) Waist circumference ( 28552196)
Interacting Genes		20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3	3 interacting genes: AMBRA1 UBQLN1 UBQLN2
Entrez ID		55626	51144
HPRD ID		10975	09989
Ensembl ID		ENSG00000110497	ENSG00000149084
Uniprot IDs		A0A075B6T1 Q9C0C7	Q53GQ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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