AMBRA1 and CREM

		AMBRA1	CREM
Description		autophagy and beclin 1 regulator 1	cAMP responsive element modulator
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Chromatin Nucleus Transcription Regulator Complex Cytoplasm ATF4-CREB1 Transcription Factor Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding CAMP Response Element Binding Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Signal Transduction Spermatogenesis Cell Differentiation Rhythmic Process
Pathways		Macroautophagy
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diarrhoea-associated Entamoeba histolytica infection ( 30228239) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3	47 interacting genes: AMBRA1 ATF1 ATXN1 BHLHE40 CAMK2D CAMK2G CASP8AP2 CDC34 CDK1 CREB1 CREB3L1 CREBBP CSNK1A1 CSNK2A1 CSNK2A2 CUL2 DNMT3L EMP3 FHL5 GLIS2 GSK3A GSK3B HDAC1 HPCA HPCAL1 KCNIP3 MAPK3 MKNK1 MYOZ3 NCALD NCS1 PIAS3 POU2F1 PRKACA PRKCA RHOXF2 ROR2 RUSC1 SNRPB SNRPC SP100 SPI1 TAF4 TBP UBAP2 UBE2I VENTX
Entrez ID		55626	1390
HPRD ID		10975	00444
Ensembl ID		ENSG00000110497	ENSG00000095794
Uniprot IDs		A0A075B6T1 Q9C0C7	Q03060
PDB IDs
Enriched GO Terms of Interacting Partners?
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