AMBRA1 and SLC35C1

		AMBRA1	SLC35C1
Description		autophagy and beclin 1 regulator 1	solute carrier family 35 member C1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Autophagosome Cytosol Axoneme Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm	Golgi Membrane Golgi Apparatus Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding GTPase Binding	GDP-fucose Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Nervous System Development Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Mitochondrial Depolarisation	Carbohydrate Transport Lipid Glycosylation Protein O-linked Fucosylation GDP-fucose Import Into Golgi Lumen Negative Regulation Of Notch Signaling Pathway
Pathways		Macroautophagy	Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) GDP-fucose biosynthesis Transport of nucleotide sugars
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Immunoglobulin A ( 20694011) Insulin-related traits (multivariate analysis) ( 32002517) Normal facial asymmetry (angle of deformation score) ( 30631343) Schizophrenia ( 28991256 29483656 30285260) Selective IgA deficiency ( 27723758)	Axial length ( 24144296) Diastolic blood pressure ( 26969751) Visceral fat ( 22589738)
Interacting Genes		20 interacting genes: ALX4 BECN1 CHUK CREM CUL4B GABARAP GABARAPL1 GABARAPL2 HSD17B12 KBTBD4 MAP1LC3A MAP1LC3B MAP1LC3C MTCH2 MTOR PEX11A RNF2 SLC35C1 SNCA UBE2D3	1 interacting genes: AMBRA1
Entrez ID		55626	55343
HPRD ID		10975	09324
Ensembl ID		ENSG00000110497	ENSG00000181830
Uniprot IDs		A0A075B6T1 Q9C0C7	B3KQH0 Q96A29
PDB IDs
Enriched GO Terms of Interacting Partners?
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