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RBX1 and UBE2E1
Number of citations of the paper that reports this interaction (PubMedID
31560077
)
2
Data Source:
BioGRID
(pull down)
RBX1
UBE2E1
Description
ring-box 1
ubiquitin conjugating enzyme E2 E1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
ISG15 Transferase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Reactive Oxygen Species
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Histone Monoubiquitination
Protein Ubiquitination
ISG15-protein Conjugation
Histone H2B Ubiquitination
Protein K48-linked Ubiquitination
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
Antigen processing: Ubiquitination & Proteasome degradation
ISG15 antiviral mechanism
Inactivation of APC/C via direct inhibition of the APC/C complex
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
Regulation of APC/C activators between G1/S and early anaphase
APC/C:Cdc20 mediated degradation of mitotic proteins
Phosphorylation of the APC/C
APC-Cdc20 mediated degradation of Nek2A
Separation of Sister Chromatids
Senescence-Associated Secretory Phenotype (SASP)
CDK-mediated phosphorylation and removal of Cdc6
Transcriptional Regulation by VENTX
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Academic attainment (English) (
33594131
)
Acne (severe) (
24927181
)
Extremely high intelligence (
29520040
)
Metabolite levels (
23823483
)
Interacting Genes
76 interacting genes:
APP
ARIH1
CAND1
CAND2
CCND1
CCNK
CDC34
CDKN1B
CFLAR
COPS4
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DESI1
DTL
EP300
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
GRAP2
HAX1
KCTD17
KIDINS220
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NTHL1
OS9
PBX4
PML
PMM1
PRAME
RHOBTB3
RNF126
RPS6KB1
S100A12
SEPTIN3
SERTAD1
SFTPD
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
113 interacting genes:
ARIH2
ASXL2
BARD1
BIRC7
BIRC8
BRCA1
CADPS2
CBL
CBWD5
CHFR
CNOT4
CUL3
DTX1
DTX3
DTX3L
DZIP3
EPS15
F12
FBXO2
FBXO7
HDAC6
IPO11
ITCH
JADE1
LRSAM1
MAP3K1
MARCHF2
MARCHF3
MARCHF5
MARCHF7
MDM2
MGRN1
MID1
MKRN3
MUL1
NEDD4
NEDD4L
NHLRC1
OTUB1
PAEP
PBX2
POLL
POLM
PRKN
RBX1
RELA
RFWD3
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF128
RNF13
RNF130
RNF14
RNF150
RNF152
RNF165
RNF166
RNF167
RNF168
RNF169
RNF181
RNF185
RNF2
RNF20
RNF26
RNF31
RNF4
RNF40
RNF43
RNF5
RNF8
STUB1
TOPORS
TRAF6
TRIM17
TRIM2
TRIM21
TRIM23
TRIM27
TRIM28
TRIM29
TRIM3
TRIM32
TRIM33
TRIM37
TRIM38
TRIM39
TRIM45
TRIM50
TRIM69
TRIM7
UBA1
UBA7
UBASH3B
UBE2G1
UBE3A
UBOX5
UBR7
UFM1
USP7
UVSSA
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
9978
7324
HPRD ID
06794
04225
Ensembl ID
ENSG00000100387
ENSG00000170142
Uniprot IDs
P62877
A0A024R2K3
B7Z306
P51965
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
7B5L
7B5M
7B5N
7B5S
1XR9
3BZH
4JJQ
5LBN
6FGA
Enriched GO Terms of Interacting Partners
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