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RBX1 and OS9
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
87
Data Source:
BioGRID
(two hybrid)
RBX1
OS9
Description
ring-box 1
OS9 endoplasmic reticulum lectin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Hrd1p Ubiquitin Ligase Complex
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Protease Binding
Protein Binding
Carbohydrate Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Reactive Oxygen Species
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting
Protein Retention In ER Lumen
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Response To Endoplasmic Reticulum Stress
Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
Antigen processing: Ubiquitination & Proteasome degradation
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Brain morphology (MOSTest) (
32665545
)
Multiple sclerosis (
31604244
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Interacting Genes
76 interacting genes:
APP
ARIH1
CAND1
CAND2
CCND1
CCNK
CDC34
CDKN1B
CFLAR
COPS4
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DESI1
DTL
EP300
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
GRAP2
HAX1
KCTD17
KIDINS220
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NTHL1
OS9
PBX4
PML
PMM1
PRAME
RHOBTB3
RNF126
RPS6KB1
S100A12
SEPTIN3
SERTAD1
SFTPD
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
28 interacting genes:
ACP1
ACVR1B
CPNE6
CREB3
DCSTAMP
DYSF
EGLN1
EGLN3
EIF6
FAIM2
FOXM1
GLS2
HIF1A
HSP90B1
LINC00839
MEP1B
P3H3
PGD
PTH
RBX1
SCN8A
SLC22A1
SMAD2
SNRPD2
SREBF2
TRPV4
UVRAG
ZNF512B
Entrez ID
9978
10956
HPRD ID
06794
17804
Ensembl ID
ENSG00000100387
ENSG00000135506
Uniprot IDs
P62877
Q13438
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
7B5L
7B5M
7B5N
7B5S
3AIH
Enriched GO Terms of Interacting Partners
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