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RBX1 and GHR
Number of citations of the paper that reports this interaction (PubMedID
25505247
)
12
Data Source:
BioGRID
(unspecified method)
RBX1
GHR
Description
ring-box 1
growth hormone receptor
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Extracellular Region
Extracellular Space
Nucleus
Mitochondrion
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Integral Component Of Membrane
Cytoplasmic Ribonucleoprotein Granule
Neuronal Cell Body
Receptor Complex
Growth Hormone Receptor Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Cytokine Receptor Activity
Growth Hormone Receptor Activity
Protein Binding
Peptide Hormone Binding
Growth Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cytokine Binding
SH2 Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Proline-rich Region Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Response To Reactive Oxygen Species
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Autoubiquitination
Endocytosis
Receptor Signaling Pathway Via JAK-STAT
Hormone-mediated Signaling Pathway
Cytokine-mediated Signaling Pathway
Taurine Metabolic Process
Response To Food
Cellular Response To Insulin Stimulus
Cellular Response To Hormone Stimulus
Regulation Of Multicellular Organism Growth
Positive Regulation Of Multicellular Organism Growth
Hormone Metabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Response To Morphine
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Cell Differentiation
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Response To Glucocorticoid
Cartilage Development Involved In Endochondral Bone Morphogenesis
Growth Hormone Receptor Signaling Pathway
Response To Interleukin-1
Negative Regulation Of Neuron Death
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
ROS sensing by NFE2L2
ROS sensing by NFE2L2
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
Antigen processing: Ubiquitination & Proteasome degradation
Prolactin receptor signaling
Growth hormone receptor signaling
Growth hormone receptor signaling
Drugs
Somatotropin
Pegvisomant
Somatrem
Somapacitan
Diseases
GWAS
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
LDL cholesterol levels (
32203549
)
Neuroticism (
29255261
)
Refractive error (
32231278
)
Blood protein levels (
30072576
29875488
)
Familial squamous cell lung carcinoma (
29924316
)
Heel bone mineral density (
30598549
)
Height (
28552196
25429064
31562340
)
Hip circumference adjusted for BMI (
34021172
)
Iron status biomarkers (
19084217
)
Menarche (age at onset) (
25231870
)
Plasma renin activity levels (
29650764
)
Response to taxane treatment (docetaxel) (
23006423
)
Systemic lupus erythematosus (
18204098
)
Interacting Genes
76 interacting genes:
APP
ARIH1
CAND1
CAND2
CCND1
CCNK
CDC34
CDKN1B
CFLAR
COPS4
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DESI1
DTL
EP300
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
GRAP2
HAX1
KCTD17
KIDINS220
KPNB1
KRTAP12-2
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NTHL1
OS9
PBX4
PML
PMM1
PRAME
RHOBTB3
RNF126
RPS6KB1
S100A12
SEPTIN3
SERTAD1
SFTPD
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
45 interacting genes:
AP2A1
BTRC
CISH
CLCC1
CUL1
CUL5
DUSP7
ELOB
ELOC
FBXO31
GH1
GH2
GRB10
GRB2
IRS1
JAK1
JAK2
NCOA6
NEDD8
PIK3R1
PIK3R2
PLCG1
PTPN1
PTPN11
PTPN13
PTPN2
PTPN3
PTPN6
PTPN9
PTPRB
PTPRH
RBX1
RNF7
SGTA
SHC1
SKP1
SOCS1
SOCS2
SOCS3
SRPK2
STAT3
STAT5A
STAT5B
STUB1
TYK2
Entrez ID
9978
2690
HPRD ID
06794
02971
Ensembl ID
ENSG00000100387
ENSG00000112964
Uniprot IDs
P62877
A0A087X0H5
A0A087X162
P10912
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
6R6H
6R7F
6R7H
6R7I
6R7N
6TTU
7B5L
7B5M
7B5N
7B5S
1A22
1AXI
1HWG
1HWH
1KF9
2AEW
3HHR
5OEK
5OHD
Enriched GO Terms of Interacting Partners
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