UCHL1 and LAMP2

Number of citations of the paper that reports this interaction (PubMedID 18550537)
84

Data Source:
HPRD (in vivo)

		UCHL1	LAMP2
Description		ubiquitin C-terminal hydrolase L1	lysosomal associated membrane protein 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Extracellular Space Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Platelet Dense Granule Membrane Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Membrane Raft Extracellular Exosome Integral Component Of Autophagosome Membrane Membrane Microdomain Ficolin-1-rich Granule Membrane Lysosomal Matrix
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	Protein Binding Enzyme Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Population Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Protein Targeting Cellular Response To Starvation Protein Import Regulation Of Protein Stability Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Establishment Of Protein Localization To Organelle Autophagosome Maturation Lysosomal Protein Catabolic Process
Pathways		UCH proteinases	Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	5 interacting genes: AP4M1 APLNR CTSA PIAS4 UCHL1
Entrez ID		7345	3920
HPRD ID		01877	02396
Ensembl ID		ENSG00000154277	ENSG00000005893
Uniprot IDs		P09936 V9HW74	P13473
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ	2MOF 2MOM
Enriched GO Terms of Interacting Partners?
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