UCHL1 and USP21

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		UCHL1	USP21
Description		ubiquitin C-terminal hydrolase L1	ubiquitin specific peptidase 21
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm	Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Ubiquitin Binding	Transcription Coactivator Activity Thiol-dependent Deubiquitinase Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Population Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Neuromuscular Process Muscle Cell Development Cellular Response To Xenobiotic Stimulus	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated
Pathways		UCH proteinases	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 HSP90AA1 HSPA8 LAMP2 MYCBP2 NCAM1 NEDD8 PLA2G2A RANBP9 SHANK3 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28	61 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350
Entrez ID		7345	27005
HPRD ID		01877	05291
Ensembl ID		ENSG00000154277	ENSG00000143258
Uniprot IDs		P09936 V9HW74	Q9UK80
PDB IDs		2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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