CD44 and COL1A2

Number of citations of the paper that reports this interaction (PubMedID 1730778)
111

Data Source:
HPRD (in vitro)

		CD44	COL1A2
Description		CD44 molecule (Indian blood group)	collagen type I alpha 2 chain
Image
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Plasma Membrane Integral Component Of Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Secretory Granule Membrane Lamellipodium Membrane Macrophage Migration Inhibitory Factor Receptor Complex Cell Projection Extracellular Exosome	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Collagen Binding Hyaluronic Acid Binding	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process	Inflammatory Response Cell Adhesion Cell-matrix Adhesion Cell Migration Cytokine-mediated Signaling Pathway Hyaluronan Catabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Heterotypic Cell-cell Adhesion T Cell Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Wound Healing, Spreading Of Cells Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cartilage Development Positive Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Cell-cell Adhesion Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Regulation Of Lamellipodium Morphogenesis	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly
Pathways		Degradation of the extracellular matrix Cell surface interactions at the vascular wall Integrin cell surface interactions Hyaluronan uptake and degradation Neutrophil degranulation Interferon gamma signaling	GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization
Drugs		Bivatuzumab Hyaluronic acid
Diseases
GWAS		Bone mineral density (hip) ( 30172743) Glycemic traits (pleiotropy) ( 31021400) Intake of sweets ( 31005972) Response to Vitamin E supplementation ( 22437554) Systemic lupus erythematosus ( 27399966 23273568 26502338 28714469) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Uterine fibroids ( 31649266) Vitiligo ( 27723757 22561518)	Aging ( 22773346) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		70 interacting genes: ABCB5 AKT1 ANK1 ARHGEF1 ARHGEF12 ARNT BDNF CAT CCND2 CD4 CD74 CDK4 CDK6 CDKN2A CDKN2B COL14A1 COL1A1 COL1A2 CSK CSTF3 DMP1 DPT EGFR EPB41 EPHA2 ERBB2 ERBB4 EZR FGF2 FGFR4 FN1 FYN GARS1 GLIS2 GRM1 HBEGF HMMR IGFBP3 KDELR2 LATS2 LCK LMO2 MADCAM1 MAP2K3 MAP2K5 MAP3K13 MDM4 MET MMP1 MMP7 MMP9 MSN NF2 NONO PDGFRA PKN1 RAF1 RIMS2 SELE SPP1 SRC SRD5A1 SRGN STK11 TGFBR1 TGFBR2 TIAM1 VAV2 VCAN VHL	31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF
Entrez ID		960	1278
HPRD ID		00115	00363
Ensembl ID		ENSG00000026508	ENSG00000164692
Uniprot IDs		P16070	A0A0S2Z3H5 P08123
PDB IDs		1POZ 1UUH 2I83 4PZ3 4PZ4 6TXS	5CTD 5CTI 5CVA 6JEC
Enriched GO Terms of Interacting Partners?
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