COL1A2 and ITGA2B

Number of citations of the paper that reports this interaction (PubMedID 11359786)
51

Data Source:
HPRD (in vivo)

		COL1A2	ITGA2B
Description		collagen type I alpha 2 chain	integrin subunit alpha 2b
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type I Trimer Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome	Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Membrane Extracellular Exosome Blood Microparticle
	Molecular Function	Protease Binding Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity Identical Protein Binding SMAD Binding Metal Ion Binding Platelet-derived Growth Factor Binding	Protein Binding Identical Protein Binding Metal Ion Binding Extracellular Matrix Binding Fibrinogen Binding
	Biological Process	Skeletal System Development Blood Vessel Development Transforming Growth Factor Beta Receptor Signaling Pathway Rho Protein Signal Transduction Regulation Of Blood Pressure Extracellular Matrix Organization Collagen Fibril Organization Bone Mineralization Collagen Metabolic Process Odontogenesis Skin Morphogenesis Protein Heterotrimerization Cellular Response To Amino Acid Stimulus Extracellular Matrix Assembly	Positive Regulation Of Leukocyte Migration Cell-matrix Adhesion Integrin-mediated Signaling Pathway Platelet Aggregation
Pathways		GPVI-mediated activation cascade Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Syndecan interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Scavenging by Class A Receptors GP1b-IX-V activation signalling Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) MET activates PTK2 signaling Collagen chain trimerization	Platelet degranulation Integrin cell surface interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			Abciximab Tirofiban Lefradafiban Fradafiban
Diseases
GWAS		Aging ( 22773346) Heel bone mineral density ( 30598549) Immune reponse to smallpox (secreted IL-12p40) ( 22610502) Intelligence ( 22449649) Low bone mineral density (hip) ( 26235824) Low bone mineral density (spine) ( 26235824) Mean forced vital capacity from 2 exams ( 17903307) Post bronchodilator FEV1 ( 26634245) PR interval in Tripanosoma cruzi seropositivity ( 24324551)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494 27863252) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 32888494)
Interacting Genes		31 interacting genes: APP BGN CD36 CD44 CD93 COL5A3 DCN EIF3F FN1 ITGA2 ITGA2B ITGB3 KCNIP4 LIG4 LUM MESD MMP9 MYOC P4HB PDGFA PDGFB SERPINB5 SGTA SGTB SHBG SMARCD1 SPARC TGFBI UBQLN1 UBQLN2 VWF	20 interacting genes: APP AUP1 CALR CAMK2A CD36 CIB1 CLNS1A COL1A2 COL2A1 F2 FGA FGG FN1 GRB2 ITGB3 PLA2G4A PRKACA SHARPIN TLN1 VWF
Entrez ID		1278	3674
HPRD ID		00363	06377
Ensembl ID		ENSG00000164692	ENSG00000005961
Uniprot IDs		A0A0S2Z3H5 P08123	P08514
PDB IDs		5CTD 5CTI 5CVA 6JEC	1DPK 1DPQ 1JX5 1KUP 1KUZ 1M8O 1RN0 1S4W 1TYE 1UV9 2K1A 2K9J 2KNC 2MTP 2N9Y 2VC2 2VDK 2VDL 2VDM 2VDN 2VDO 2VDP 2VDQ 2VDR 3FCS 3FCU 3NID 3NIF 3NIG 3T3M 3T3P 3ZDX 3ZDY 3ZDZ 3ZE0 3ZE1 3ZE2 4CAK 4Z7N 4Z7O 4Z7Q 5HDB 6V4P
Enriched GO Terms of Interacting Partners?
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