FXR2 and TRIOBP

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		FXR2	TRIOBP
Description		FMR1 autosomal homolog 2	TRIO and F-actin binding protein
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Presynapse Dendritic Filopodium	Nucleus Cytoplasm Microtubule Organizing Center Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Positive Regulation Of Response To DNA Damage Stimulus	Actin Filament Organization Cell Cycle Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 25631615 28073927) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		187 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTD DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 VIM WDR59 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	10 interacting genes: DNAL4 FXR1 FXR2 GTF2H1 HECTD3 IKBKG PLK1 POLR1C TSC1 VIM
Entrez ID		9513	11078
HPRD ID		05629	11028
Ensembl ID		ENSG00000129245	ENSG00000100106
Uniprot IDs		P51116	Q9H2D6
PDB IDs		3H8Z
Enriched GO Terms of Interacting Partners?
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