TRIOBP and DNAL4

		TRIOBP	DNAL4
Description		TRIO and F-actin binding protein	dynein axonemal light chain 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base	Cytoplasm Microtubule Plasma Membrane Cilium Dynein Complex
	Molecular Function	Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding	Microtubule Motor Activity Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Actin Filament Organization Cell Cycle Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Microtubule-based Movement
Pathways			Retrograde neurotrophin signalling
Drugs
Diseases
GWAS		Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 25631615 28073927) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		10 interacting genes: DNAL4 FXR1 FXR2 GTF2H1 HECTD3 IKBKG PLK1 POLR1C TSC1 VIM	25 interacting genes: CACNA1I CAMK2D CHIC2 DDX17 DYNLL1 DYNLL2 FHL5 GNA14 GPBP1 GTPBP1 HMGXB4 JOSD1 KRTAP10-3 KRTAP12-3 KRTAP9-8 NFATC2IP NOTCH2NLA NTAQ1 NUDT22 RHOT2 SCTR TOM1 TRIM54 TRIOBP UBA7
Entrez ID		11078	10126
HPRD ID		11028	13239
Ensembl ID		ENSG00000100106	ENSG00000100246
Uniprot IDs		Q9H2D6	O96015
PDB IDs
Enriched GO Terms of Interacting Partners?
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