FXR2 and FMR1

Number of citations of the paper that reports this interaction (PubMedID 7489725)
106

Data Source:
HPRD (in vivo, in vitro)

		FXR2	FMR1
Description		FMR1 autosomal homolog 2	FMRP translational regulator 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Axon Growth Cone Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Presynapse Dendritic Filopodium	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Extrinsic Component Of Plasma Membrane Axon Dendrite Growth Cone Filopodium Tip Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Dendritic Spine Neck Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Messenger Ribonucleoprotein Complex Growth Cone Filopodium Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity Translation Regulator Activity Protein Heterodimerization Activity	G-quadruplex RNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding Methylated Histone Binding SiRNA Binding MiRNA Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Sequence-specific MRNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Negative Regulation Of Translation Regulation Of MRNA Stability Positive Regulation Of Translation Regulation Of Filopodium Assembly Positive Regulation Of Response To DNA Damage Stimulus	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization MRNA Processing Cellular Response To DNA Damage Stimulus Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Histone Phosphorylation Cellular Response To UV Regulation Of MRNA Stability Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion MRNA Transport Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Gene Silencing By MiRNA Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Cellular Response To Hydroxyurea Cellular Response To Virus Regulation Of Neuronal Action Potential Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Binding Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Response To DNA Damage Stimulus
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Brain morphology (MOSTest) ( 32665545) IgM levels ( 23118916) Monocyte count ( 32888494) Refractive error ( 32231278) Sex hormone-binding globulin levels ( 22675492)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)
Interacting Genes		187 interacting genes: AKAP9 AMOTL2 AP1M1 AP2M1 ARHGEF7 ARL6IP1 ATN1 AXIN1 AXIN2 BAZ2B BCKDK BCL11A BLK BRCA1 BYSL C10orf62 C1orf35 CALCOCO2 CAMK2B CAMK2G CAPRIN1 CBS CCAR2 CCDC33 CCDC85B CCDC92 CCN3 CCR4 CDKL3 CEP44 CEP55 CHRD COIL COMT CSNK2B CWF19L2 CYFIP1 CYFIP2 DCTD DCTN2 DCTPP1 DDX17 DEAF1 DGKD DMRTB1 DNM2 DPPA2 DYNLT1 ECH1 ECHS1 EDC4 EGFL7 EIF4G1 EVL EWSR1 FAM90A1 FBP1 FMR1 FTH1 FXR1 GFAP GKAP1 GOLGA2 GPSM1 GPSM2 GRIP1 GTSE1 HIVEP1 HMBOX1 HNRNPC HNRNPM HNRNPR HOMER3 HSPB1 IGFN1 IMPDH2 INPP5J KCNRG KCTD4 KHDRBS1 KIAA1217 KIF1A KIF2A KIF7 KRT18 KRT20 KXD1 L3MBTL1 L3MBTL3 LASP1 LCMT1 LCP2 LDOC1 MAGED1 MAPKBP1 MAPRE3 MBIP MCRS1 MEAF6 MFAP1 MIA3 MORF4L1 MPP1 MRPL43 MSANTD3 MVP MYH10 NASP NCK2 NDEL1 NDN NECAB2 NEXN NIF3L1 NKD2 NME1 NME3 NONO NT5C2 PAF1 PAICS PCBD1 PCM1 PDE9A PHC1P1 PHC2 PHLDB1 PICK1 PIM1 PKM PNMA1 POM121 PPP1R12C PRAM1 PRC1 PSME1 PSME3 PTS PYCR2 PYCR3 RABAC1 RAD54L2 RAI2 RALYL RBBP8 RBM14 RBM45 RBMX RBPMS RPIA RTN3 RTN4 SCEL SCMH1 SF3B2 SFPQ SNAP23 SPRY1 SPRY2 SYT6 SYTL4 TBC1D22B TFCP2 THAP1 TLE5 TNFAIP1 TNIP2 TNNT1 TRAF2 TRIM23 TRIM29 TRIM3 TRIM37 TRIOBP TSC22D4 TUT4 VIM WDR59 YES1 ZBTB22 ZBTB8A ZMAT2 ZMYND8 ZNF232 ZNF451 ZNRD2 ZSCAN1	48 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 SRC STAU1 SUOX TACC2 UBE2I WBP2NL YBX1 ZBTB42 ZFPM2 ZMYND8
Entrez ID		9513	2332
HPRD ID		05629	02398
Ensembl ID		ENSG00000129245	ENSG00000102081
Uniprot IDs		P51116	Q06787
PDB IDs		3H8Z	2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?
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