PICK1 and NECTIN2

Number of citations of the paper that reports this interaction (PubMedID 15811349)
12

Data Source:
HPRD (two hybrid)

		PICK1	NECTIN2
Description		protein interacting with PRKCA 1	nectin cell adhesion molecule 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity
Pathways		Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization
Drugs
Diseases
GWAS		Body fat percentage ( 26833246) Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 32888494)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)
Interacting Genes		376 interacting genes: ABT1 AEBP2 AFDN AKT1 AKT2 ALKBH8 AP1M1 AP1S1 APTX AQP1 ARF1 ARF3 ARHGEF3 ARHGEF5 ARL6IP1 ARMCX1 ASIC1 ASIC2 ATP5IF1 ATXN1L ATXN3 ATXN7 ATXN7L3 AVPI1 BAHD1 BCL2L14 BEX1 BLK BLOC1S2 BOLA3 BRD1 BTG2 BUD31 BYSL C1orf35 C2CD5 C4orf46 C8orf33 CACNA1C CACNA1I CARD9 CBX8 CCDC102B CCDC103 CCDC187 CCNH CDC42EP2 CDC73 CDCA7L CDK2AP1 CDKL3 CDKN2B CDKN2D CEP19 CEP290 CEP57L1 CEP89 CEP95 CGGBP1 CHMP1B CIC COIL CPNE2 CPNE7 CRY2 CSNK2A2 CTNNB1 CTSG CUTC CWF19L2 CYP21A2 DCTD DCUN1D5 DDX55 DDX6 DLG4 DMC1 DMD DNAJB13 DNMT1 DNTTIP1 DNTTIP2 DPF2 DRAP1 DTNB DUSP29 EAF1 EEF2KMT EFHC2 EFNB1 EFNB2 EHD2 EHHADH EIF1AD EIF3D EIF4A3 EIF4EBP1 EIF4H EIF5A ENKD1 EPHB2 EPM2AIP1 ERBB2 ERBIN ESCO2 EXOSC5 F11R FAM161A FAM161B FAM214B FAM219B FAM90A1 FAM9A FBXL3 FBXL8 FGF16 FKBP6 FLYWCH1 FMR1 FXN FXR2 GADD45GIP1 GAS2L2 GFI1 GFI1B GLYCTK GPATCH11 GPATCH2 GPC4 GPKOW GRB10 GRB7 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 GRXCR1 GTF2E2 GTPBP2 HDAC4 HEXIM2 HMBOX1 HMBS HMG20A HOPX HOXA5 HSD17B14 HSF2 HSF2BP ID2 IHO1 IL16 ILF2 INO80B INO80E INPP5J IP6K1 ISCU JAM3 JRK KAT5 KCTD1 KCTD6 KCTD9 KIAA1328 L3MBTL2 LCLAT1 LCN2 LGALS14 LMO1 LMO3 LONRF1 LRP2BP LRRC73 LZTFL1 LZTS1 MAGEA4 MAGEB4 MAP2K6 MAPK9 MAPRE3 MAZ MBD3 MCM10 MEOX2 MGME1 MID2 MNS1 MOB3C MORF4L1 MORF4L2 MORN3 MOS MRI1 MRNIP MSRB3 MSS51 MTA1 MTG1 NATD1 NCOA5 NDEL1 NECAB2 NECTIN2 NECTIN4 NEK6 NLGN3 NME7 NMNAT1 NOC4L OARD1 OPTN OSBP2 OSGIN1 OSTF1 PAFAH1B3 PAX6 PBX4 PCBD1 PDCD5 PDS5A PEBP1 PHF19 PIBF1 PKN1 PKNOX2 PLEKHA7 PNKP PNO1 POLL POLR3C PPARA PPL PRKCA PRKCG PRKN PRLHR PRPF18 PRPF31 PRPF40A PSMA1 PSME3 PTEN PTRH1 QARS1 RAD51D RASAL3 REEP6 REL RFC3 RIMS3 RIN1 RNF8 RNPS1 ROBO3 ROPN1 RPIA RPP25 RRP8 RXRB RXRG SACS SCAND1 SCNM1 SEMA3B SEPTIN1 SERBP1 SERTAD1 SERTAD3 SH2D4A SH3GLB2 SHFL SLC6A3 SLIRP SLX9 SMARCA2 SMARCB1 SMARCD1 SNRNP25 SNRPA1 SNRPB2 SNW1 SPANXN2 SPATC1L SPEG SSNA1 STK19 STK4 SYT17 TBC1D22B TBC1D26 TBC1D7 TCEA2 TCEANC TCEANC2 TDO2 TEX101 TFIP11 THAP6 THAP7 TLE5 TLNRD1 TPM4 TRAF4 TRAF5 TRIM44 TRIM54 TRIML2 TRMT2A TSC1 TSC2 TSGA10IP TSN TSTD2 TTC23 TTC23L TXNDC9 TXNL4B TYW3 UBE2E3 UBE2K UBQLN4 USHBP1 USP2 USP7 UTP3 VAX1 VEZF1 VPS25 WT1 XPA YES1 YPEL2 YTHDC1 ZBED1 ZBTB2 ZBTB24 ZBTB49 ZFHX3 ZFP2 ZFP91 ZMAT2 ZMYND12 ZNF165 ZNF17 ZNF205 ZNF250 ZNF264 ZNF276 ZNF286A ZNF329 ZNF330 ZNF35 ZNF408 ZNF410 ZNF414 ZNF417 ZNF438 ZNF497 ZNF524 ZNF575 ZNF576 ZNF593 ZNF624 ZNF691 ZNF71 ZNF764 ZNF774 ZSCAN21 ZSCAN23 ZZZ3	37 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 PVR RGS20 SIAH1 TCF4 TGM1 TIGIT USP53
Entrez ID		9463	5819
HPRD ID		16176	02879
Ensembl ID		ENSG00000100151	ENSG00000130202
Uniprot IDs		A0A024R1J5 Q9NRD5	Q92692
PDB IDs		2GZV 6AR4 6BJN 6BJO	3R0N 4DFH 4DFI 4HZA 5V52
Enriched GO Terms of Interacting Partners?
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