NECTIN2 and CD226

Number of citations of the paper that reports this interaction (PubMedID 12913096)
278

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		NECTIN2	CD226
Description		nectin cell adhesion molecule 2	CD226 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Cell Surface Integral Component Of Membrane Apical Junction Complex Cell-cell Contact Zone Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Raft
	Molecular Function	Virus Receptor Activity Protein Binding Coreceptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	Integrin Binding Protein Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Acrosome Assembly Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Spermatid Development Spermatid Nucleus Differentiation Fertilization Fusion Of Virus Membrane With Host Plasma Membrane Sperm Mitochondrion Organization Cell Part Morphogenesis Positive Regulation Of Mast Cell Activation Susceptibility To Natural Killer Cell Mediated Cytotoxicity Adhesion Of Symbiont To Host Cilium Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Viral Entry Into Host Cell Coreceptor-mediated Virion Attachment To Host Cell Positive Regulation Of T Cell Receptor Signaling Pathway Establishment Of Mitochondrion Localization Susceptibility To T Cell Mediated Cytotoxicity	Cytokine Production Positive Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Adhesion Signal Transduction Cell Recognition Positive Regulation Of Interferon-gamma Production Positive Regulation Of Mast Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 30498476) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Urate levels ( 31578528)	Autoimmune thyroid disease ( 32581359) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic widespread musculoskeletal pain ( 33331911) Eosinophil counts ( 32888494) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean platelet volume ( 22139419 19820697 31194788 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary sclerosing cholangitis ( 23603763 27992413) Reticulocyte fraction of red cells ( 32888494) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 33272962) Type 1 diabetes ( 21829393 25751624 17554260) White blood cell count ( 32888494)
Interacting Genes		37 interacting genes: AFDN ATP5MF CD226 CYSRT1 DUS2 HOXA1 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP12-2 KRTAP5-9 LCE1C LCE2B LCE2C LCE5A LYRM4 MAPK6 MDFI MEOX2 NBPF19 NECTIN3 NECTIN4 NOTCH2NLA NR4A3 P4HB PICK1 PVR RGS20 SIAH1 TCF4 TGM1 TIGIT USP53	8 interacting genes: CNDP2 DOK6 FYN GALR1 ITGB2 NECTIN2 PVR TSHZ1
Entrez ID		5819	10666
HPRD ID		02879	09252
Ensembl ID		ENSG00000130202	ENSG00000150637
Uniprot IDs		Q92692	J3QR77 Q15762
PDB IDs		3R0N 4DFH 4DFI 4HZA 5V52	6ISB 6O3O
Enriched GO Terms of Interacting Partners?
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