HOMER3 and CCDC141

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		HOMER3	CCDC141
Description		homer scaffold protein 3	coiled-coil domain containing 141
Image			No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Dendrite	Cytoplasm Centrosome Neuron Projection
	Molecular Function	Protein Binding G Protein-coupled Glutamate Receptor Binding Identical Protein Binding	Protein Binding
	Biological Process	Protein Targeting G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Store-operated Calcium Entry	Cerebral Cortex Radially Oriented Cell Migration Centrosome Localization
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Blood pressure measurement (cold pressor test) ( 24165912) Diastolic blood pressure ( 28135244 27841878 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 30166351 23583979) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Left ventricular ejection fraction ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular global circumferential strain ( 33495596) Left ventricular mass ( 33495596) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Number of live births ( 30188897) Number of pregnancies ( 30188897) Objective response to lithium treatment ( 26503763) PR interval ( 32439900) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale) ( 28525603) Pulse pressure ( 30578418) QRS duration ( 30012220) QT interval ( 24952745 29874175) Resting heart rate ( 29769521 27798624) Serum polyunsaturated fatty acid concentration x Mediterranean diet adherence interaction in metabolic syndrome ( 31991592) Sick sinus syndrome ( 33580673) Smoking cessation ( 30617275)
Interacting Genes		92 interacting genes: ABI1 ABI2 ABI3 APP ARL13B C1orf116 C4orf17 CCDC120 CCDC141 CCDC187 CDC37 CDK18 CEBPB CWF19L2 DVL3 DYNLL1 DYNLL2 EAF1 EFHC1 EIF3D FAM161B FAM90A1 FAT1 FBXO28 FMR1 FRYL FXR1 FXR2 GAS8 GDF15 GGN GRM5 HOMER1 HOXB5 INCA1 ITPR1 KANK2 KANK4 KDM1A KRTAP19-7 LHX2 LNX1 LRRC7 LSM14B MDM1 MEOX1 MFAP1 MIA3 MOS MSS51 NEBL NTAQ1 OTX2 PALLD PAX6 PAX7 PKN1 PLAAT5 POLI POM121 PPP1R18 PPP1R32 PRCC PRR35 PSMA1 PSMA2 PSMC5 PSORS1C2 RBM14 RBM22 RUNX1T1 RYR1 SAXO1 SCNM1 SDCBP SHANK3 SLAIN1 SMR3B SNRPF SRPK2 TBC1D22B TOX2 TRPC1 TSC1 USP2 WBP2 WIPF1 ZBTB4 ZNF19 ZNF35 ZNF414 ZNF655	4 interacting genes: DISC1 HOMER3 RRAD TSC22D2
Entrez ID		9454	285025
HPRD ID		07270	08257
Ensembl ID		ENSG00000051128	ENSG00000163492
Uniprot IDs		Q9NSC5	B8ZZB3 Q6ZP82
PDB IDs		2P8V 3CVF
Enriched GO Terms of Interacting Partners?
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