DLG5 and DLST

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLG5	DLST
Description		discs large MAGUK scaffold protein 5	dihydrolipoamide S-succinyltransferase
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Adherens Junction Postsynaptic Density Cell Junction Ciliary Basal Body	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Centriolar Satellite Oxoglutarate Dehydrogenase Complex
	Molecular Function	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Acyltransferase Activity
	Biological Process	Epithelial To Mesenchymal Transition Signal Transduction Negative Regulation Of Cell Population Proliferation Maintenance Of Cell Polarity Negative Regulation Of Cell Migration Polarized Epithelial Cell Differentiation Midbrain Development Negative Regulation Of Hippo Signaling Positive Regulation Of Hippo Signaling Intracellular Signal Transduction Negative Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Synapse Assembly Epithelial Tube Branching Involved In Lung Morphogenesis Positive Regulation Of Dendritic Spine Development Protein-containing Complex Assembly Protein Localization To Adherens Junction Metanephric Collecting Duct Development Cell-cell Adhesion	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation
Pathways		RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 34315874 33339817) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 33547301 34315874) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 22001757) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Retinal detachment or retinal break ( 31816047) Serum alkaline phosphatase levels ( 33547301)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Eosinophil counts ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		8 interacting genes: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1	19 interacting genes: ACYP1 ARIH2 CCDC86 DLG5 ESRRB FLII NAP1L1 NDRG1 OGDH OGT PAK4 PFN2 RUSC2 SCFD1 SIAH2 TUBB4B UMPS ZBTB16 ZHX1
Entrez ID		9231	1743
HPRD ID		04972	00520
Ensembl ID		ENSG00000151208	ENSG00000119689
Uniprot IDs		Q8TDM6	A0A024R6C9 B7Z6J1 P36957
PDB IDs		1UIT	6H05
Enriched GO Terms of Interacting Partners?
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