MTA2 and USP11

Number of citations of the paper that reports this interaction (PubMedID 31504778)
9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down, imaging technique)

		MTA2	USP11
Description		metastasis associated 1 family member 2	ubiquitin specific peptidase 11
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	Transcription Corepressor Binding Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Chromatin Remodeling Regulation Of Fibroblast Migration Histone Deacetylation Positive Regulation Of Transcription By RNA Polymerase II	Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	Association of TriC/CCT with target proteins during biosynthesis Ub-specific processing proteases
Drugs
Diseases
GWAS		Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	22 interacting genes: BMI1 BRCA2 CBX8 CDKN1A DECR2 EIF4B LIMS1 LLGL1 MBD3 MTA2 NONO PCGF2 PML RANBP9 RELB RNF2 RPS6KB1 SETDB1 SUMO2 TBL3 TP53 UBC
Entrez ID		9219	8237
HPRD ID		07233	02081
Ensembl ID		ENSG00000149480	ENSG00000102226
Uniprot IDs		A0A024R534 O94776	B4DGK3 P51784
PDB IDs			4MEL 5OK6
Enriched GO Terms of Interacting Partners?
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