DERL3 and IL27RA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		DERL3	IL27RA
Description		derlin 3	interleukin 27 receptor subunit alpha
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Integral Component Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex
	Molecular Function	Signal Recognition Particle Binding Protein Binding Protein-containing Complex Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity
	Biological Process	Protein N-linked Glycosylation Via Asparagine Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation
Pathways		ABC-family proteins mediated transport Defective CFTR causes cystic fibrosis	Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Ejection fraction ( 29403010) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Left ventricular internal dimension in systole ( 29403010) PR interval ( 32439900) S-phenylmercapturic acid levels in smokers ( 26959369)	Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		19 interacting genes: EHHADH GAD2 GNLY GPR101 IL27RA MELTF NDRG4 PSCA RTP4 SDCBP SERPINA1 SLC13A4 STATH SYT16 TEX29 TMEM179B TMEM31 TMEM92 ULBP2	13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6
Entrez ID		91319	9466
HPRD ID		13139	09247
Ensembl ID		ENSG00000099958	ENSG00000104998
Uniprot IDs		Q96Q80	Q6UWB1
PDB IDs
Enriched GO Terms of Interacting Partners?
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